Abstract
Of 21 dogs with allergic dermatitis, 10 were medicated with 10 mg/kg tranilast for 2.8 weeks while 12 with 1 mg/kg oxatomide for 4.7 weeks including one case given both drugs. Six (60%) tranilast-medicated and 6 (50%) oxatomide-medicated cases showed responses to the treatment with mean improvement rates of 47.8% and 46.4%, respectively, as assessed by the method of Halliwell. Normal 14 dogs were administered for 30 days either with 10 or 60 mg/kg of tranilast, or with 1 or 10 mg/kg of oxatomide, and the inhibitory effect in mast-cell degranuation was evaluated by measuring skin wheal size at the injection site after intradermal injection with compound 48/80 and histamine phosphate. Significant effects were observed only in cases treated with 10 mg/kg oxatomide.
