Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Effect of Bucillamine on Rheumatoid Arthritis in a Dog
Tomokazu NAKAIMitsuyoshi NAKAGAWAChio YOSHIDAHiromi FURUTSUYoshiharu SHIMADAKazuro MIYAHARAMotoyoshi SATOTsuneo HIROSE
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1994 Volume 47 Issue 7 Pages 496-498

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Abstract

A 7-year-old female Toy Poodle weighing 2.1kg showed joint swelling and angular deformity with pain and lameness. Radiography revealed luxation with severe destruction of joints and periarticular soft tissue swelling. Hyperglobulinemia with increased levels of alpha2, beta and gammaglobulin fractions was observed. After administrating of bucillamine, an immunomodulator, clinical signs of affected joints were significantly improved in accordance with decreasing gamma globulin, suggesting that immunologic mechanism might be involved in this case of canine rheumatoid arthritis.

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