Effect of Thiamphenicol on Bovine Bacterial Respiratory Disease

Abstract

Effect of watersoluble thiamphenicol (TP), VII-65, for bovine bacterial respiratory disease was examined, as compared with that of ABPC. TP was administered at 10mg/kg (16 cases), 20mg/kg (25 cases), or 30mg/kg (26 cases) for 3 successive days, and ABPC was at 10mg/kg (16 cases). Temperature was improved significantly (P<0.001 or 0.01) in the all groups, but respiratory rate, vigor and appetite were not improved significantly in ABPC group, and recovery rate in the TP group was higher. From the nasal swabs Pasteurella multocida and Mycoplasma bovis were isolated from in 14 of 27 (51.9%) and 5 of 27 (18.5%) samples, respectively. The P. multocida isolates were highly susceptible to TP and ABPC, but no M. bovis isolate was sensitive to ABPC.