Abstract
The plasma concentrations of chlormadinone acetate (CMA) in female cats were determined by GC-MS with the quantitaion limit of 0.2ng/ml. After intravenous injection of CMA solution, the half-life was 27 hr. After subcutaneous implantation of pellet (TZV-802) in female cats, plasma CMA concentration was maintained during 28 days, showing a half-life of 138 hr. The bioavailability of pellet implantation was about 100%.
