1997 Volume 50 Issue 8 Pages 470-474
Absorption, distribution and excretion of a new quinolon derivative, orbifloxacin (OBFX), were studied in dogs and cats given a single dose of 5mg/kg. The pharmacokinetic parameters of OBFX were almost similar after either subcutaneous or oral route administration. The AUC0-∞ in cats given intravenous, subcutaneous and oral doses were almost the same. The satisfactory distribution of OBFX was observed in various tissues of dogs and cats given subcutaneous dose, and the levels were higher than the plasma levels in most of tissues. After subcutaneous injection of OBFX, the urinary recoveries (0-72hrs) were 45.4% and 28.3%, in dogs and cats respectively, while the fecal recoveries were 17.7% and 15.4%.
