A total of 250 broiler chicken heads from 10 (A-J) farms were examined in April to June 1996 grossly, revealing caseous exudate within the air spaces of cranial bones and middle ears in 3 chickens of farm A and 2 each of farms B and C. Histopathologically, granulomatous lesions with foreign body-type giant cells were obseved in the air spaces of cranial bones and middle ears, suggesting that the lesions might be of chronic or recovery phase of the swollen head syndrome (SHS).
From September to November 1995, serological survey revealed that 75% of farms and 61.5% of sentinel calves examined were positive for antibodies to Aino virus (AIV) in the southern Okayama Prefecture. Six cases of congenital abnormalities were observed from November 1995 to March 1996, 5 of 6 cases were of stillbirth at 8 to 9 months of pregnancy. Five and 4 of them showed cervical gryposis and arthrogryposis, respectively, while one showed cerebral defect and cerebellar hypoplasia. Viruses were isolated from erythrocytes and blood plasma from three sentinel calves in early October 1995, and the dates of sero-conversion and virus isolation suggested fetal infection occurring at 3 to 5 months of pregnancy. The isolates had physicochemical properties of AIV and cross-reacted with the JaNAr-28 strain in neutralizing test.
In a pig farm, weaning piglets aged 35 to 45 days, acutely died showing shaking of the eyes and systemic convulsion, and growing pigs aged 60 to 90 days showed anorexia, cough, dyspnea, limping with arthritis, and cyanosis and died within 4 days. The mortalities of weaning and growing pigs in September were 9.8% and 10.7%, respectively. While no specific lesions were found in weaning piglets, fibrinous pericarditis, pleurisy, pneumonia, peritonitis with turbid cerebrospinal and synovial fluids were observed in growing pigs. Streptococcus suis was isolated from the heart, lung, liver, kidney, brain, and knee joints in both weaning and growing pigs. Ammoxicillin or sulfamonomethoxine-orimetoprim combination were administered in drinking water resulted in decreased mortality.
Twenty-two cases of canine epulides, fibrous (10 cases), granulomatous (7 cases), fibromatous (4 cases), and acanthomatous (1 case), were epizootologically and histopathologically investigated. There was no predisposition in canine breeds and sexes (9 males and 10 females), and most cases were of adult dogs (8.3 years of age on average). The lesions were mostly localizd around the anterior teeth (11 cases), or the posterior teeth (9 cases), occuring on the labial or buccal side of gingiva except for one case on the palatal side. Ossification was noted in 6 of 22 cases.
Absorption, distribution and excretion of a new quinolon derivative, orbifloxacin (OBFX), were studied in dogs and cats given a single dose of 5mg/kg. The pharmacokinetic parameters of OBFX were almost similar after either subcutaneous or oral route administration. The AUC0-∞ in cats given intravenous, subcutaneous and oral doses were almost the same. The satisfactory distribution of OBFX was observed in various tissues of dogs and cats given subcutaneous dose, and the levels were higher than the plasma levels in most of tissues. After subcutaneous injection of OBFX, the urinary recoveries (0-72hrs) were 45.4% and 28.3%, in dogs and cats respectively, while the fecal recoveries were 17.7% and 15.4%.
A nodular lesion approximately 2 cm in diameter was detected in the liver of a slaughted two-year-old bullock. Histopathologically, the central necrotic focus was surrounded by epithelioid cells and multinucleated giant cells with proliferation of fibroblasts and infiltration of lymphocytes. The filamentous microorganisms were present in the lesions and were positively stained with Gram, Ziehl-Neelsen and Grocott methods as well as with immunostain using antiserum to Nocardia asteroides ATCC 19247.