Abstract
Plasma clearance of inulin for estimating glomerular filtration rate (GFR) was evaluated in 8 normal cats under a conscious condition. Areas under the clearance curve (AUC) were determined with 11 or 12 plasma samples by 2 common pharmacokinetic analyses, the two-compartment model (2-CM) and the computer generated nonlinear regression analysis (NLR). AUC was also determined by NLR in case where the number of samples was reduced to 6. There was no significant difference between AUCs determined by 2-CM and NLR with 6 samples and between the resulting AUCs and computed GFRs using inulin dosage. The regression line between AUCs determined by 2-CM and NLR with 6 samples and between computed GFRs using inulin dosage and the AUCs showed an excellent fitness based on p value and coefficient of determinations.
