Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
CombinedIn VitroEffects of Orbifloxacin and Fosfomycin on S. Dublin and S. Typhimurium Isolated from Calves
Shuji MATSUMOTONoriyuki KITADAIKatsuhisa NAKATAHiromi KATAE
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JOURNAL FREE ACCESS

2000 Volume 53 Issue 1 Pages 1-6

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Abstract

This study determined minimal inhibitory concentrations (MIC) of orbifloxacin (OBFX), fosfomycin (FOM), and several antibacterial agents againstSalmonella Dublin andSalmonellaTyphimurium isolated from calves. For 90% of the isolates tested, MICs of OBFX were 1.56μg/mlagainst S. Dublin and 0.2μg/mlagainst S. Typhimurium. Antibacterial potencies of OBFX against tested organisms were higher than those of oxolinic acid (OA), kanamycin (KM), gentamicin (GM), oxytetracycline (OTC), ampicillin (ABPC), sulfamethoxazole (SMX), trimethoprim (TMP), fosfomycin (FOM), and bicozamycin (BCM). All isolates were considered susceptible to OBFX, FOM, GM, TMP, and BCM. After establishing these properties, we assessed the combined effect of OBFX and FOM in an attempt to determine efficacy against infections caused byS. Dublin andS. Typhimurium. The checkerboard method was used to examine the combinedin vitro effect of OBFX and FOM. Fractional inhibitory concentration (FIC) indices of OBFX-FOM combinations against 5 strains of S. Dublin and S. Typhimurium ranged from 0.313 to 1.03, suggesting that the combined effects of these 2 agents are additive or synergistic. The effects of the 2 agents were additive or synergistic in 88.2% of all FIC indices. In timekilling experiments, the combined effects of OBFX and FOM on 2 strains ofS. Dublin were found to be synergistic.

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