A Case of Bovine Viral Diarrhea Virus 1 Infection Accompanied by Thrombocytopenia and Petechiae

Abstract

A case of infection with the bovine viral diarrhea virus 1 (BVDV1) with clinical signs of infection with the BVD virus 2 (BVDV2) was observed on a farm on Hokkaido. The affected cow showed thrombocytopenia, fever, and petechiae in the mucous membrane, diarrhea, and leukopenia after calving. The neutralizing antibody titer to the BVDV1 was 2, 048, but no virus was isolated from BFM (bovine fetal muscle) cell cultures inoculated with the animal's serum. Sequencing of PCR products revealed the virus to be BVDV1. These findings suggest that BVDV1 infection and/or calving may cause clinical symptoms.