2001 Volume 54 Issue 11 Pages 821-826
Eight Holstein dairy cows demonstrating chronic diarrhea and edema shortly after parturition were examined clinicopathologically and pathologically. Because clincopathological findings included marked hypoproteinemia, hypoalbuminemia, and proteinura, all cases were suspected of manifesting the nephrotic syndrome. But pathogenesis could not be identified, andthe condition was clinically difficult to distinguish from amyloidosis. Necropsy findings included distinctly enlarged kidneys. In histopathological examinations, focal-segmental or global sclerotic lesions of the glomeruli were commonly observed.