2002 Volume 55 Issue 12 Pages 799-804
The effects of propionylpromazine(0.05mg/kg IV; PRP, n=30)were compared with those of acepromazine(0.05mg/kg; ACP, n=30)as premedication before inhalation anesthesia of dogs. Surgical anesthesia was induced with ketamine 5mg/kg IV and maintained with 50% nitrous oxide-50% oxygen-sevoflurane. After pre-medication, all dogs became calm and relaxed and demonstrated moderate sedation. After injections of keta-mine, convulsions occurred in 1 dog in the ACP group and in 2 dogs in the PRP group. After induction of anes-thesia, apnea occurred in 8 dogs in the ACP group and 10 dogs in the PRP dogs. Controlled ventilation was required to improve ventilation and/or to maintain surgical anesthesia in 7 dogs in the ACP group and 4 dogs in the PRP group. End-tidal sevoflurane concentration during surgery varied between 2.0 and 2.2%. During surgery, body temperatures dropped below 36 t in 12 dogs in the ACP group and in 13 dogs in the PRP group. Hypothermia(<35.0°C)developed in 3 dogs in each group. Throughout surgery in both groups, heart rate, respiratory rate and partial pressure of end-tidal CO2were maintained within normal canine limits: 120 bpm, 25 bpm, and 40mmHg, respectively. Hypotension occurred in 6 dogs in each group. Recovery from anesthesia was rapid, and most dogs were extubated 10 minutes after anesthesia cessation. No differences between the premedication effects of propionylpromazine and acepromazine were apparent. Both are useful as premedica-tion for dogs.
