Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Antibiotic Sensitivities of Mycobacterium avium Isolated from Pigs and the Diagnostic Significance of IFN-γProduced by Lymphocytes Stimulated with a Specific Antigen in Swine Mycobacteriosis
Akira IWAKIRISatoshi GANNITHIDAIkuo OGATAShigeki YAMAMOTOYoshitaka GOTO
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2004 Volume 57 Issue 2 Pages 117-120

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Abstract

Multiplex PCR tests identified 69 strains of mycobacteria originated in pigs from 5 Japanese meat-inspection centers as Mycobacterium avium (M. avium). The sensitivities of 24 strains to 9 antibiotics were tested. All strains were shown to be 8 times more sensitive to streptomycin, rifampicin, clarithromycin, and amikacin than is indicated by previously reported data on M. avium strains originating in human beings [10]. Measurements of interferon-gamma (IFN-γ) production by spleen cells or blood monocytes isolated from normal or infected pigs showed that IFN-γwas produced in the swine-mycobacteriosis group if they were stimulated by the M. avium antigen in vitro. No production was observed in the healthy control group. This suggests that IFN-γassay is a valuable method for diagnosis of M. avium infection in swine.

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