2008 Volume 61 Issue 1 Pages 39-42
To establish an effective vaccination program for bovine viral diarrhea (BVD) and infectious bovine rhinotracheitis, cattle were inoculated with commercial polyvalent vaccines which contain inactivated BVD virus, which were seronegative for BVD virus and bovine herpes virus 1. A single shot of the vaccines induced little antibody response in these cattle. One month after the second vaccination, a significant presence of neutralizing antibodies was detected in cattle and antibody titers decreased gradually. It was also demonstrated that an additional shot of the vaccines at 12 months after the first vaccination induced antibody response enough to prevent manifestation of disease signs. On the basis of the present results, two vaccinations and an annual
