Abstract
In a 16-year-old female spayed Shetland Sheepdog with a principal complaint of acute lameness and anorexia, a multifocal splenic mass and multiple lytic bone lesions were found through abdominal ultrasonography and radiography, respectively. Serum and urine electrophoresis failed to reveal a monoclonal spike. Because of the danger of rupture, a splenectomy and liver mass resectional biopsy were performed. A pathological examination produced a diagnosis of plasma cell neoplasm and hepatocellular carcinoma. An additional examination of bone mallow aspiration and osteolytic lesion biopsy showed nonsecretory multiple myeloma. A combination of chemotherapy and bisphosphonate resulted in clinical improvements, but the dog died on the 162th day.
