結核菌株ノ單獨並ニ複合眼前房内接種ニヨル家兎ニ對スル毒性ニ就テ(續報)

抄録

In a previous experiment^*, several strains of tubercle bacilli of. the human type which were different from each other in their virulence were injected seperately or jointly into the anterior cham-ber of the rabbit's eye, and it became known that their pathogene-city becomes more intensified, when injected jointly than when inoculated seperately.
In the present experiments, the BCG strain together with a virulent strain of human type, both mixed in various ratios, was inoculated into the anterior chamber of rabbit's eye, and the tuber-culous changes developed in the eye and in other organs were observed.
The arrangement of the experiments and results obtained are as follows:
(1) The pathogenecity of the tubercle bacilli studied was compared by inoculations in the 5 following combinations:
I) 0.005mg. tubercle bacilli of human type.
II) 0.0005mg. tubercle bacilli of human type.
III) 1.0mg. BCG.
IV) 0.005mg. tubercle bacilli of human type+1.0mg. BCG.
V) 0.0005mg. tubercle bacilli of human type+0.1mg. BCG.
(2) The grade of tuberculous changes in the eye runs paral-lel with that in other organs. The pathogenecity was found the highest in IV, next in V, far lower in I and II, and the lowest in III.
(3) It was thus recognized that the pathogenecity of tuber-cle bacilli is more intensely displayed by the mixed inoculation than by the seperate infection.
(4) It is noteworthy that a quantity of BCG inefficient to cause any decided change, when inoculated by itself, shows a conspicuous pathogenecity, when inoculated jointly with an insig-nificant amount of virulent human strain of tubercle bacilli.
(5) It may be concluded, therefore, that the BCG strain, when inoculated together with a virulent strain, displays a marked pathogenecity rather than a preventive effect.