抄録
By irtvestigating the milk components of alcohol positive milk brought about by liverdysfunction it was proved that some contents, not to speak of ionized calcium, changequalitatively and quantitatively. Therefore, it is thought that the occurrence of alcoholpositive milk may be due to a dysfunction of the mammary gland which performs milkproduction.In this paper, in order to clarify the mechanism of alcohol positive milk caused byliver dysfunction, the mammary glands of lactating goats in which there was a liver dys-fur?ction such as described in the previous paper No. 2, were examined biochemically, andhistologically. Moreover, 2 or 3 factors in relation to the liver and mammary gland func-tions, were studied.The results obtained from these experiments are as follows.l) TTC reduction ability, alkaline-phosphatase activity, and the components such asDNA, PNA, acid-soluble-P and lipid-P, in the tissues of the mammary glands, weredetermined. The activity of enzymes, and various other components, tended to be lowerin value in the experimental groups than in the control groups. During the histologicalexaminatuon of the mammary tissue, apocrination, hyperplasy and atrophy of alveoli, cellinfiltration and hypertroplxy of the interalveolar and interlobular tissue, were fotund.These changes were similar to those found in mastitis circumscripta. But, the degree ofinflammation in the mammary tissue was weaker in the case of alcohol positive milk thanin the case of mastitis. In the goat from the experimental groups producing alcohol negativemilk, there were found slight biochemical arnd histological changes in the mammary glands.These facts might show that cows and goats which have either natural or experimentallyproduced liver dysfunction do not always secrete alcolnol positive milk. These lactatinganimals may be considered to produce alcohol positive milk probably when their marnmaryglands have become functionally disordered.2) The various factors in the relationship between liver disorder and the function ofthe rnarnmary glands were studied. As one of these studies, the calcium balance wasexamined in the case of lactating goats producing alcohol positive milk, since the occurrenceof alcohol positive milk is presumed to have some relation to the metabolism of calcium.From tlne experiments, the decrease of the calcium in the blood of goats having liverdisorder vzas noted. On the contrary, inorganic phosphorus had a tendency to increase ingeneral. It is thought that these changes are probably due to hypoparathyroidism. Thealcohol positive milk of lactating goats was produced by the adrruinistration of a greatdeal of thyroid hormone. In these goats serum calcium decreased, and calcium in theurine irtcreased. These changes were thought to be a symptom of hypoparathyroidism.From these facts, one of the causes of alcohol positive milk which is brought about byliver disorder is thought to be the abnormality of the marnmary gland as a result ofhypoparatltyroidism.3) It has been mentioned- that the mammary gland is influenced by estrogen andprogesterone, and since inactivation of estrogen in the liver decreases when there is liverdysfunction, goats such as these beconre hyperestrogenism.It apjvears that
