Abstract
Pathological studies were carried otzt on cerebrocortical necrosis in fotzr offive heifers affected in a group of 12 rearing calves. These calves were kept in an isolatedbarn on a fattening farm of moderate scale, and fed moulded hay harvested two yearsbefore. Clinical observation revealed diarrhea followed by the typical nervous symp[ontsof the disease and leucocytosis. Macroscopically, the edematous turbid meninges yellowishbrown in color with hemorrhagic spots, and softening of the yellowish zonal area corresponding to the gray matter were demonstrated in the cerebral hemisphere. Ilistologicalobservation disclosed neuronal necrosis, edema[ous degeneration of astrocytes, proliferation of compound granular corpuscles, and vascularization with swollen endothelial cellsin the gray matter. Pyramidal cell necrosis, edematous enlargement of the cytoplasrn andprocesses of degenerative glia cells, degenerative disorder of the neuropil in the lesionwere observed by electron microscopy. Discussion was made on the pathogenesis of thedisease.
