Abstract
Forestomach ulcer of rat which resembles with swine gastroesophageal ulcer developed in 100% of starved rats reared with glucose solution for 5 days. This incidence rate was much higher than that observed in water given rats. Examining the difference of ulcer incidences between 2 groups, the enhancement of gastric secretion attended by a large amount of drinking may be a causative factor. In that gastric expansion due to drinking a large amount of glucose solution may cause to stimulate gastric secretion. Forestomach mucosa may be attacked more vigorously by the increased secretion of gastric acid and pepsin. This causative process of the ulcer development may be similar to that of the swine ulcer. Antiulcerogenic test of following 5 substances on the forestomach ulcer was also performed; pepstatin, NaHCO3, carboxy-methylcellulose, sodium polyacrylate (PAS) and sodium alginate (AGS). Among them pepstatin (an antipeptic), PAS (a thickening agent) and AGS (a thickening agent or anti-heartburn agent) were evaluated to be effective prophylactic agents. Now we are in contemplation to examine their effectiveness on the naturally occurring or experimentally induced swine ulcer.
