Abstract
Intrasinus free phagocytes ingesting injected colloidal carbon (CC) or alum-precipitated bovine serum albumin (AP-BSA) migrated through the lymphatic cords into the lymphatic nodules, and those with CC became situated in clusters around or inside the germinal centers. Horseradish peroxidase (HRP) also showed a similar intranodal pathway but often mediated by the. reticulum cells in the lymphatic cords and nodules as well as the free phagocytes. This confirms the sequential cooperation of free macrophages and regional lymphocytes during the initial stages of the intranodal immune response.
