The Japanese Journal of Veterinary Science
Online ISSN : 1881-1442
Print ISSN : 0021-5295
ISSN-L : 0021-5295
Role of Thymus-Dependent Lymphocytes and Antibodies in Feline Infectious Peritonitis after Oral Infection
Toshiharu HAYASHINobuo SASAKIYasushi AMIKosaku FUJIWARA
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1983 Volume 45 Issue 6 Pages 759-766

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Abstract
Sero-negative kittens were inoculated intragastrically with feline infectious peritonitis (FIP) virus after thymectomy and/or treating with immune serum or immune ascites against FIP virus. At necropsy performed 10 days postinoculation, thymectomized kittens showed severer intestinal lesions than did non-treated controls. The kittens that had received high-titered serum or ascites with or without thymectomy were found to have fibrinous peritonitis. Peritonitis was severer in the thymectomized and antibody-treated kittens. The results suggest that the virus caused damage to the thymus-dependent lymphocytes and that the humoral antibody played some role in inducing serositis as well as parenchymatous organ lesions.
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