Abstract
Intestinal emphysema was observed in two male ICR-mice of twelve months of age. Gas-filled cysts of various sizes were located on the wall of the cecum and colon, and mesentery. Histopathologically, a thin layer of endothelium-like cells which occasionally observed multinucleate giant cells among them, covered the inside of the cysts. These cysts were surrounded by thin fibrous tissue and inflammatory cells. No bacteria could be detected in the lesions.