Population Shift from Piliated to Non-piliated Bacteria in Kidneys, Bladder and Urine of Mice Infected with Corynebacterium renale Strain No. 115 Piliated Bacteria

Abstract

The shift of population from piliated (P⁺) to non-piliated (P^-) bacteria was found in the kidneys, bladder and urine of the mice inoculated into the bladder with 10^8.4 or more of Corynebacterium renale strain No. 115 P⁺ bacteria. The results suggested that there was apparent selective in vivo growth of P^- bacteria, which were originally present small in number in the population of inoculated P⁺ bacteria. The shift from P⁺ to P^- bacteria was not found only in the mice with anti-pili antibodies response positive, nor was it accelerated by passive immunization of mice with anti-pili antiserum.