The Japanese Journal of Veterinary Science
Online ISSN : 1881-1442
Print ISSN : 0021-5295
ISSN-L : 0021-5295
O-Demethylation and N4-Acetylation of Sulfadimethoxine by the Snail Cepaea hortensis
Tom B. VREE, Monika L. VREE, Eleonora W. J. BENEKEN KOLMER, Yechiel A. HEKSTER, Minoru SHIMODA, Jacques F. M. NOUWS, Toshiyuki YOSHIOKA, Kazuhiko HOJI
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Keywords: O-demethylation, snail, sulfadimethoxine, 2-demethyl (=hydroxy) sulfadimethoxine
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1989 Volume 51 Issue 2 Pages 364-368

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Abstract
The snail Cepaea hortensis O-dealkylates sulfadimethoxine at the 2- and 6-position, the 2-position being favoured. Sulfadimethoxine is also acetylated, while no measurable acetylation of the hydroxy (=demethyl) metabolites took place.
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