Therapeutic Effects of Varidase on the Bacillary Dysentery Ulcer

Abstract

Varidase, a enzymatic drug containing streptokinase and streptodornase, originates from nonpathogenic hemolytic streptococci and is widely used as an antiphlogistic. It was given by the author in combination with TC to bacillary dysentery patients admitted to the municipal Ebara Hospital in order to investigate effects of Varidase on the rectum ulcer caused by dysentery bacilli. Varidase was administered in the following methods:
I. One tablet each of Varidase Buccal was given perorally 4 times a day in timeinterval of 6 hours.
II. One tablet each of Varidase Buccal was given intrarectally 4 times a day in time interval of 6 hours.
III. One vial of Varidase Topical was dissolved in l0ml of distilled water, 2m1 of which was again diluted with luke warm saline solution to 100m1 and this was very slowly infused once a day into the rectum.
Just before and after the treatmnt and prior to the discharge from the hospital, rectoscopy was performed in order to compare the effects of the 3 methods on rectum ulcer with those of antibiotica or chemical drugs in alone use. Out of 5 cases treated with the latter, antibiotica or chemical drugs were effective in 2 cases and non-effective in 3 cases. The above mentioned method I, however, was effective in 2 out of 3 cases, method II excellently effective in 1, and effective in 4 out of 5 cases, method III excellently effective in 6, effective in 6 out of 12 cases.
Consequently, every of the 3 methods, especially method III was evidently more effective on rectum ulcer as compared with the other methods (antibiotica or chemical drugs), though a larger number of cases are required to obtain more accurate results.