Combined Use of Matromycine and Panfran S against Dysentery Bacilli

I Report: With Special Reference to Therapeutic Experiences of Resistant Dysentery Bacilli

Abstract

Combined therapy of Matromycine and Panfran S in equal dosis (50 mg each for children, 4 times a day for five days) was carried out against 58 cases of bacillary dysentery.
The results were as follows:
i) Reappearance of the bacilli was observed in 8 out of the 58 cases (13.8%) and in 6 out of 38 dysentery cases (15.8%) caused by resistant bacilli.
ii) Reappearance of dysentery bacilli, whenitreated with a single antibiotic, occurred in 59.6% of infant cases caused by resistant bacilli, whereas in the combined therapy only 5 out of 18 infant cases (27.8%) due to resistant bacilli demonstrated the reappearance.
iii) Clinical effects such as disappearance of bacilli, recover of stool nature, decrease of the number of stools etc. were remarkable in this combined therapy.
iv) Any of the side effects such as nausea, vomitting, abdominal pain, epigastrial uncomfortableness, anorexia and headache was scarcely noticed in all the cases treated with the combined therapy.