島根県松江地方におけるエンテロウイルス感染症の調査成績 (1968)

抄録

Enteroviruses were detected during April to December, 1968, on 290 samples of cerebrospinal fluids, throat swabs and feces materials of 221 patients visiting medical practitioner's offices or general hospitalsin Matsue city, Shimane prefecture and giving suspicion of viral infections. Most of the samples were from the department of pediatrics of Matsue Red Cross Hospital and Dr. Nishino's office.
In some of them, neutralization tests for Cox. B5 were paralleled by paired sera.
Besides, the results of a serological survey carried out in Decembeir, 1967, the previous year, on a number of Children.at the age, 0-14, were presented as a discussion for 1968's prevalence of aseptic meningitis in this city.
The summary is as follows:
1) Of all 290 materials, 84 were revealed as enterovirus positive; 25 out of 66 cerebrospinal fluids, 6 out of 58 throat swabs and 53 out of 166 feces materials. Thus, 60 patients out of 221 were virologically positive, the rate being 27.1%.
2) Isolation rate in every clinical diagnosis was 72.5% in aseptic meningitis, 33.3% in myalgia, 19.2% in what was tentatively diagnosed as fever disease, and 6.7% in herpangina. No viruses were isolated in 21 cases of pharyngitis, 1 case of stomatitis aphthosa, two cases of hand-foot-and-mouth disease, and other 10 cases.
3) The viruses were most frequently isolated in July and August. Ages of the cases were mostly within 0-7.
4) In aseptic meningitis, isolation rate is particularly high (51.8%) in cerebrospinal fluids.
5) No particular relation between cell count of cerebrospinal fluid and virus isolation rate is reognized.
6) Isolation rate was visibly higher in the case of specimens sent from the medical practitioners' than from the general hospitals. The gap was particularly wide in the case of cerebrospinal fluid. One of the reasons seemed to be procedural deficiency, such as delay in transportation, on the part of the general hospitals.
7) Neutralization tests for Cox. B5 were paralleled in 8 cases; 3 of them were Cox. B5-positive aseptic meningitis, 3 were virus-negative aseptic meningitis and two others were virus negative. Except one virusnegative aseptic meningitis case who had already shown positive at 16 folds in tht earlier serum, the later sera of all cases rose 4 times or over than the earlier ones in the antibody titer.
8) In serological investigations performed in December, 1967, the antibody possessing rate for Cox. B5 was null in the healthy children tested of 0-3 years age and low even in the age group 4-14. This fact is thought to be one of the main causes of 1968' prevalence of aseptic meningitis in this city.