A case of advanced hepatocellular carcinoma with hepatitis C virus infection treated effectively with Peg-IFNα2a

Abstract

A 59-year-old man with hepatitis C virus infection who had undergone micro wave coagulation therapy for 2 cm of hepatocellular carcinoma (HCC) in 2004 developed multiple recurrence in January 2011 and referred to our hospital. In spite of hepatic artery chemo embolization therapy, sorafenib, hepatic arterial infusion chemotherapy, and oral S-1, the tumors increased in size and number. Serum AFP and PIVKA II levels were also elevated. After administration of 180 μg of Peg-INFα-2a every week, the levels of AFP and PIVKA II had markedly decreased. Eleven months after the initiation of 180 μg of Peg-INFα-2a treatment, the multiple hepatic tumors and lung metastases which were observed during the course disappeared. Although the recurrence of S3 appeared afterward, lobectomy of left lobe segment was successfully performed, resulting in normalization of serum AFP and PIVKAII. Peg-IFNα-2a might be a possible therapeutic option for advanced HCC.