Morphological study on the initial lesions of experimental primary biliary cirrhosis

Abstract

We extended morphological study on 84 rahbits through the immunization with antigen prepared from fresh bovine gallbladder mucouse membrane in order to clarify the initial lesions and its incidence.
In 47 out of 84 rabbits (56%), preicholangitis with and without granuloma was founded out. In addition, chronic non-suppurative destructive chonlangitis was recognized in six rabbits. This fact indicated that experimental primary biliary cirrhosis model was induced through our experimental methods.
And there's no corellations between the frequency of immunization and the incidence of chronic non-suppurative destructive cholangitis and pericholangitis, therefore it was thought that the individual differential sensitivity existed in the provocation and the development of the disease.