末梢血単核細胞のmitogenによる活性化に及ぼすKupffer細胞の影響

新井 孝之; 溝口 靖紘; 宮島 慶治; 池本 吉博; 筒井 ひろ子; 加藤 寛子; 山本 祐夫; 森沢 成司

doi:10.2957/kanzo.25.1546

The effect of Kupffer cells on mitogen-induced lymphocyte transformation

Takayuki ARAI, Yasuhiro MIZOGUCHI, Keiji MIYAJIMA, Yoshihiro IKEMOTO, Hiroko TSUTSUI, Hiroko KATO, Sukeo YAMAMOTO, Seiji MORISAWA

Author information

Takayuki ARAI
The Third Department of Internal Medicine, Osaka City University Medical School
Yasuhiro MIZOGUCHI
The Third Department of Internal Medicine, Osaka City University Medical School
Keiji MIYAJIMA
The Third Department of Internal Medicine, Osaka City University Medical School
Yoshihiro IKEMOTO
The Third Department of Internal Medicine, Osaka City University Medical School
Hiroko TSUTSUI
The Third Department of Internal Medicine, Osaka City University Medical School
Hiroko KATO
The Third Department of Internal Medicine, Osaka City University Medical School
Sukeo YAMAMOTO
The Third Department of Internal Medicine, Osaka City University Medical School
Seiji MORISAWA
The First Department of Biochemistry, Osaka City University Medical School

Keywords: mitogen, prostaglandin, indomethacin

JOURNAL FREE ACCESS

1984 Volume 25 Issue 12 Pages 1546-1551

DOI https://doi.org/10.2957/kanzo.25.1546

Details

Abstract

When human peripheral blood mononuclear cells were stimulated with phytohemagglutinin (PHA), pokeweed mitogen (PWM) or concanavalin A (Con A), lymohocyte transformation was induced. This mitogen-induced lymphocyte transformation was significantly inhibited by adding the culture supernatant of Kupffer cells from rats.
However, this effect of Kupffer cells on the lymphocyte transformation was partially inhibited by indomethacin.
These results suggested that suppression of lymphocyte transformation by Kupffer cells was attributable, at least in part, to the effect of prostaglandins.

Corresponding author

Register with J-STAGE for free!