Abstract
Impacts of medroxyprogesterone acetate (MPA) on hepatocarcinogenesis was investigated and the levels of sexual hormone receptors were measured in rats.
The diet containing 0.06% 3'-methyl-4-dimethylaminoazobenzen (3'-Me-DAB) was given to A, B, C, and D group for 75 days and to E, F, G, and H group for 170 days. In the former MPA was administered 0, 60, 120, and 180mg/kg/day for 100 or 150 days, respectively. In the latter it was administered 0, 30, 60, and 120mg/kg/day for 180 days, respectively. MPA was given with a gastric tube three days a week.
Inhibition of carcinogenesis (p<0.01) and the tumor growth (p<0.05), decrease in the mitotic index (p<0.05), and prolongation of the survival period (p<0.05) were observed in the MPA groups.
It was suggested that MPA inhibited hepatocarcinogenesis with 3'-Me-DAB and its effect might relate to increase in ER of the tumor-free tissue and be mediated with the tumor PR.
