Abstract
The author studied clinically, patho-anatomically, radiographically and histologically reconstruction of 43 mandibulae of rabbits observed during 60 days. Osteogemins which was prepared originally by Prof. Hieda were injected in 22 rabbits every two days. Other 21 rabbits were used as controls. About half of left mandible of both groups were resected after fixation with implanted splite. The results obtained were as follows : 1) Reconstruction of the resected mandible was promorted remarkably by intra-peri-toneal injections of 0.25 cc Osteogemin per kg every other day. a) Clinical and patho-anatomical findings : There were hardly any difference between the degree of reconstruction of the controls and that of those injected. b) Local findings : In the case of the rabbits injected, soft thickening was observed at the resected portion in 20 days, cartilaginous or osseous stiffness in 30 days, osseous stiffness in 40 days and after 40 days osseous stiffness became harder without exception. In controls a reconstruction of bone in the central part of the resected was not observed generally in 30 days and an incomplete reconstruction of bone was observed in 40∿50 days, even in 60 days the central portion of the reconstructed showed depression yet. c) Radiographic findings : In controls addition of shadows from the cut edges was the principal findings during 60 days. Most cases showed the defect of connection of shadows, but a few cases showed incomplete connection of shadows. The injected cases, the connected shadows in all regions were observed in even 10∿20 days ; on and after 40 days, form of shadow became quite normal. d) Patho-histological findings : In controls, osseous tissue production from cut edges was principal findings in 20 days. Central portion was widely filled with the granulation tissue. In 30∿40 days, young osseous tissue was found here and there in the central portion. In 50∿60 days an imperfect osseous connection was observed in resected portion, but the structure was yet incomplete. In injected group, a remarkable congestion of blood vessels and an osseous tissue were already found at the edges of the resected and a new osseous tissue was found remarkably from the whole surface of periost in the region of the resected in even 10 days. This findings showed a great difference from the case of the controls. In 30∿40 days the reconstructed bone was formed in almost anatomical structure and became the same as normal bone in 60 days. 2) Osteogemin activates hyperaemia of bone marrow and ossification from resected edges and activates the production of osteoblasts from the whole surface of periost. 3) Osteogemin has an effect on reproduction of osseous tissue but could not found remarkable influences macroscopically on the other organs.
