口腔領域各種疾患における組織 LDH に関する臨床的研究

抄録

Lactate dehydrogenase (LDH) has been studied in various human tumors ; however, the assay of this enzyme in oral diseases has rarely been documented. LDH activity and isoenzyme pattern were examined with tissues of 115 patients with different oral diseases. The results were as follows : 1. LDH activity was significantly higher (2.5-fold) in gingiva of pericoronitis than in normal gingiva, but the same isoenzyme pattern and M-subunits were seen in both. 2. LDH activity and isoenzyme pattern in the tissue of odontogenic keratocyst were different from those in the tissue of radicular cyst or of follicular cyst. The activity in odontogenic keratocyst was significantly higher than in radicular cyst (1.5-fold) and in follicular cyst (2.0-fold). The isoenzyme pattern in odontogenic keratocyst was significantly higher than in radicular cyst and in follicular cyst in LDH-5 and M-subunits. 3. LDH activity in the tissue of postoperative maxillary cyst was the same as in that of chronic maxillary sinusitis. The former was higher than the latter in LDH-5 and M-subunits. 4. LDH activity in the tissue of squamous cell carcinoma was significantly higher (2.8-fold) than in normal gingiva, but the same isoenzyme pattern and M-subunits were seen in both.