口腔扁平上皮癌における腫瘍マーカーの評価に関する研究 : とくに組織学的な予後因子との関連性について

抄録

Tumor markers, which are tumor-mediated substances, are not specific substances directly produced by tumor tissue. The use of tumor markers has been accepted as a valuable tool for diagnosis, prognosis and treatment monitoring. Seventy-two consecutive patients with oral squamous cell carcinoma treated in our department between 1990 and 1996 were entered in the study. Blood specimens were collected after informed consent was obtained from the patients with oral squamous cell carcinoma and oral benign diseases. The results were as follows : 1. The positive rates were 31.9% for carcinoembryonic antigen (CEA), 48.6% for squamous cell carcinoma (SCC) and 58.3% for immunosuppressive acidic protein (IAP) in patients with oral squamous cell carcinoma. 2. In oral squamous cell carcinoma, there was no correlation between histological prognostic factors and CEA or SCC. 3. IAP is correlated with histological malignancy. 4. The sensitivity and accuracy of the combination assay with these three tumor markers proved to be higher than those obtained with individual markers. This combination assay was associated with histological malignancy. 5. These results suggest that evaluation of these tumor markers in oral squamous cell carcinoma is valuable in the assesment of proliferative activity and grade of malignancy.