2005 Volume 59 Issue 2 Pages 80-85
We reported a case of adenoid squamous cell carcinoma manifested in the tongue of a 66-year-old man along with its histopathological and immunohistochemical findings. Histopathological examination revealed that almost the entire part of the neoplasm was characterized by pseudoglandular structures lined by cuboidal cells lacking intercellular bridges, keratinization, or other features of a squamous growth. Alucian blue (AB), mucicarmin (MC), and periodic acid schiff (PAS) stains failed to demonstrate epithelial mucin in the cytoplasm of the cuboidal cells or intraluminal substance. Immunohistochemical staining showed positive reactions against antibodies to cytokeratin (CK) and vimentin (VM), and no reaction with antibodies to epithelial membrane antigen (EMA) and factor VIII related antigen (FVIII). These findings suggested that this tumor involved the acantholysis and degeneration of a squamous cell carcinoma.
