Penicillin resistant strains and penicillin susceptible strains of Staphylococus, isolated from the mouths of cheilosis individuls, were treated with sulfamerazine natrium and the following results were obtained. 1. Strains whieh are relatively ready to acquire the penicillin resistance and strains which are not so were isolated from the same lesion. 2. Penicillin resitant strains, when exposed in vitro to sulfamerazine natrium, have soon recovered the susceptibility to penicillin. 3. Experiments on mice have offered such results as to confirm the in vitro experiment that sulfamerazine played a part in promoting the resistant strains toward acquring susceptibility to penicillin.