エタンブトールの体内分布とその代謝

抄録

The distribution and metabolism of ³H-labeled D-2, 2'-(ethylenediimino)-di-l-butanol(ethambutol)in the rat have been studied. The intraperitoneally injected ethambutol was taken up rapidly into such organs as kidney, liver or lung, and then disposed from them as rapidly as from the serum. In brain or in eyeballs, however, the radioactivity did not appear remarkably soon after the injection, but gradually accumulated later. This radioactivity, possibly of the metabolic product of ethambutol, was not so easily extracted from brain homogenate with perchloric acid, which indicates that it is firmly attached to the tissue. In the extract from brain a large quantity of metabolites of ethambutol was demonstrated on the ion exchange column chromatography. The metabolite accumulated in brain seems to be relevant to the side effect of ethambutol, the demyelination of central nervous system, especially of optic fibers.