非定型抗酸菌の諸種薬剤に対する感受性

III. Mycobacterium intracellulareに対する抗結核剤の併用効果について

抄録

The sensitivities of 20 disease associated strains of Mycobacterium intracellulare were tested ^{in vitro} using Tween Albumin liquid medium to various triple-drug combinations. The triple drug regimens tested were SM·PAS·INH, SM·INH·EB, KM·INH·EB, KM·TH·CS, RFP·EEB·INH, RFP·INH·CS, KM·EB·RFP and VM·ERFP·TH, all of which were considered as poten tially usable in the treatment of Atypical Mycobacterial Diseases.
The ratio of combination in these triple-drup regimens in this study was uniformly 1: 1: 1 in microgram. Hundred micrograms per milliliter of each drug was included in the first test tube, which was then successively doubly diluted until the 19th tube. The twentieth tube was used as a control. As the same time, single drug regimens were tested for the comparisons.
As a whole, all these triple-drug combinations showed more or less advantages upon the single drug regimens. Even the combination of SM·EPAS·EINH was not exceptional, though these three drugs usually show unfavorable effects in the separate use.
Though the combined effects in these triple-drug regimens vary rather equivocally in each strain, the combination of KM·EINH·EEB showed considerably better results than others.
Four combinations including RFP were more potent than others in their inhibitory effects. As the difference in the inhibitory effect between RFP alone and the combined regimen was rather small, the advantages of combining the drugs with RFP were further to be studied.