抗結核剤投与効果に関する実験的研究

I. 単独あるいは併用による間欠投与

抄録

Therapeutic effects of intermittent drug administration in various regimens were compared by the time-course observation of the altered fate of tissue viable counts in experimental mouse tuberculosis.
It was shown that intermittent chemotherapy with increased single dose of ethambutol (EB) or rifampicin (RFP) can gain the therapeutic effect almost comparable, if not superior, to that achieved by daily administration with divided dose of those drugs.
The effect was greatly enhanced when intermittent chemotherapy, even once a week regimen, was conducted with the combinations of isoniazid (INH) plus RFP, EB plus RFP, or INH plus EB plus RFP, but not so with INH plus EB.