ガス曝露下における結核化学療法剤の効果に関する実験的研究

第2編殺菌効果について

抄録

In the previous paper, it was reported that the bacteriostatic effect on tubercle bacilli was observed by using the silicone-coated slide culture method with various concentrations of antituber culous drugs and Kirchner's medium replacing air either with N₂, CO₂ or O₂ gas.
It is very interesting that these gases influence the bactericidal effects of antituberculous drugs.
In this report, the bactericidal effects were observed according to the length as well as concen trations of drugs used the culture time and the kind of gas.
The conclusions were as follows:
1) The bactericidal effects of various gases were minimal even if the experiment was continued for four weeks under drugless environment. And, the bactericidal effects differed greatly depending upon the drugs used.
2) Under the conditions using N₂, CO₂ or O₂ gases, the longer the contact time period with the several kinds of antituberculous drugs, the stronger the bactericidal effects.
3) With O₂ gas exposure, the bactericidal effects of several kinds of antituberculous drugs were stronger than with the exposure to N₂ or CO₂ gas.
4) With respect to the antituberculous drugs used, RFP showed the strongest bactericidal effects compared with the other drugs even in two week time period. And, the influence by the kinds of gas exposure was least in RFP.
5) The bactericidal effects of other antituberculous drugs under various gas exposure did not always show a higher grade bactericidal effects even with a higher drug concentration.