表面活性剤Triton WR-1339を用いた結核感染の修飾
1984 年 59 巻 4 号 p. 295-302
詳細
1984 年 59 巻 4 号 p. 295-302
A non-ionic detergent of Triton WR-1339 (oxyethylated tert. octyl phenol polymer) modified the course of experimental mouse tuberculous infection as to prolong theirsurvival time. Though it is not lytic to red blood cells and the lysosomes, this detergentexert a subtle effect on the biomembrane as evidenced by cold-shock experiment ofhaemolysis. This means that Triton WR-1339 has a strong affinity to the biomembrane, if not lytic. Electron-microscopy demonstrated that BCG organisms ingested intomacrophages were within the phagosome which appeared to be filled with the detergent.Discussion was made from these observations that the detergent may inhibit the interactionbetween mycobacteria and the phagosomal membrane by intervening between them thusmaking the progress of infection delayed.
