韓国におけるEnvironmental mycobacteria II. 分離菌感染マウスに対するOfloxacinの治療効果

抄録

Mice infected intravenously with Mycobacterium fortuitum, M. chelonae or M. avium complex isolated from the natural environment in Korea were subcutaneously given ofloxacin once daily, 6 times a week, from day 1 or 3 for up to 4 or 8 weeks after infection. In the case of M. fortuitum infection, incidence of the gross renal lesions and the number of organisms in the kidneys were reduced by the treatment with ofloxacin, indicating the proper efficacy of ofloxacin against M. fortuitum infection. In contrast, this agent failed to show a significant therapeutic efficacy against infections due to M. chelonae and M. avium complex.