Effcter of monoclonal antibody against suppressor T cells

Abstract

Suppressor T (Ts) cells are known to be regulatory cells in the immune responses. However, it is not still clear that Ts cells exist as one of T cell subsets. To clarify this issue, monoclonal antibody specific for Ts cells was established by immunizing armenian hamster with Ts clone^&ltg;1)>). This antibody, termed D6,stained Ts clone but not helper or killer T cell clone. D6 inhibited the suppressive activity of Ts cell induced by administration of allogeneic cell in delayed type hypersensitivity (DTH) system. Furthermore, it became clear that the expression of antigen recognized by D6 was essentiallyrequired to exert suppressive activity by Ts cells in DTH system.