2011 Volume 41 Pages 37-45
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of malignant lymphoma, is clinically and pathologicaly heterogeneous.We studied 104 cases of DLBCL with the method that Hans and coworkers developed an immunohistochemical algorithm using CD10, BCL-6 and MUM-1. 24 (23%) cases were considered germinal center B cel l type (GCB type) which expressed CD10 or BCL-6, another 80 (77%) cases were non germinal center B cell type (Non GCB type) which expressed BCL-6 or MUM-1. The tumor cells of GCB type were centroblastic or centrocytic cells, and these of Non GCB type were immunoblastic and plasmacitic cells. Fortermore we studied malignancy using Ki-67 and mitotic index. Conclusively we found no difference in malignancy between the GCB type and non GCB type groups. A immunohistochemistry woud have wide applicability and practical utility in routine clinical practice.
