The purpose of this study is to generate and characterize a microneedle that can be equipped in Bio-MEM which is applied to a developing HMS (Health Monitoring System) for the blood sugar level measurement. One of the most important subject to Bio-MEM is a microneedle with a inner diameter of 25μm and a outer one of 50μm, which mimics female mosquito's painless blood extraction mechanism. In this study, the microneedle generation was performed through (1) selection of a biocompatible material from titanium alloys by the cytotoxic assay, (2) RF magnetron sputter generating of the microtubes with a inner diameter of 25μm, a outer one of 50μm and a length of 2 mm, and (3) evaluation of the stiffness and strength by the bending tests. Consequently, the Ti-15 Mo-5 Zr-3 Al alloy microneedle generated by sputtering is not cytotoxic and possessed the practical stiffness and strength.
