Flow structure around a guide vane, installed in a diffuser of a mixed flow pump with low specific speed, was investigated experimentally. The secondary flow along the hub wall, which is caused by the vane camber and runs toward the suction side of the vane, changes to run upstream near the suction surface of the vane. Its flow unites with another secondary flow along the suction surface, which is caused by the meridian curvature and runs toward the hub wall, to form the strong vortex on the hub wall near the suction surface. This vortex induces the downstream flow along the suction surface to run toward the casing wall. This flow also unites with the flow from the leading edge along the suction surface to form another vortex on the suction surface near the casing wall. These vortices induce a circulating flow on the cross section in the downstream passage, and markedly affect the turning angle of the guide vane.