抄録
The permeability and endothelial cell morphology in rat aortae were measured. FITC-albumin was used as a tracer. The permeability was measured on the lateral side of ascending (immediately before brachiocephalic artery, A), descending (immediately after left subclavian artery, C) and thoracic segments, and on the medial side of ascending (B), descending (D) and thoracic segments. Endothelial cell morphology was observed in the same portions in which the permeability was measured. The permeabilities in A and B were higher than those of the descending and thoracic segments. The cell morphology in A and B was almost the same as in the other portions. However, the deviation values of the cell orientation to the axis of the blood vessel in A and B were higher than those of the other portions. These results indicate that endothelial cells in the ascending aorta reflect a complex blood flow pattern and that the permeable function of endothelial cells is affected by the complex blood flow.
