In this paper, we examine the anxiety at utilization of wheelchairs. When the human use wheelchairs, from the influence of environment, the human feel a sense of unease. In particular, when the human go up slopes using wheelchairs, the human feel a sense of unease. The sense of unease is under influence of the organ of vision and the vestibular organ. In this paper, we clarify the relation between the sense of unease and the vestibular organ, when the human go up slopes using wheelchairs.