Abstract
Ethynylpyridine oligomers covalently linked with saccharide templates were studied. The oligomers form chiral helical structures by intramolecular hydrogen bonds. To fix the helical structures, alkene side chains were introduced on the pyridine rings of the oligomers. By Grubbs reaction at these alkene side chains, the pitches of the helix could be bridged. Subsequently, the saccharide template was removed by the use of an acidic resin. The change of the retention time on GPC analyses suggested that the molecular size of the substrate decreased after the reaction. In addition, the CD activity was retained for the substrate, indicating that the chirality was retained even after removal of the saccharide template.
