The Keio HBOC Center: A Model of Hereditary Breast and Ovarian Cancer          Management

Yusuke Kobayashi; Kenta Masuda; Tomoko Seki; Takeo Kosaka; Minoru Kitago; Ikumi Ono; Kumiko Misu; Arisa Ueki; Tomoko Yoshihama; Aiko Nagayama; Yota Yasumizu; Yumiko Goto; Kohei Nakamura; Mamiko Yamada; Megumi Yokota; Sayaka Uchida; Mari Takeuchi; Takeru Funakoshi; Wataru Yamagami

doi:10.2302/kjm.2025-0004-OA

The Keio HBOC Center: A Model of Hereditary Breast and Ovarian Cancer Management

Yusuke Kobayashi, Kenta Masuda, Tomoko Seki, Takeo Kosaka, Minoru Kitago, Ikumi Ono, Kumiko Misu, Arisa Ueki, Tomoko Yoshihama, Aiko Nagayama, Yota Yasumizu, Yumiko Goto, Kohei Nakamura, Mamiko Yamada, Megumi Yokota, Sayaka Uchida, Mari Takeuchi, Takeru Funakoshi, Wataru Yamagami

Author information

Yusuke Kobayashi
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan
Kenta Masuda
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan
Tomoko Seki
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Takeo Kosaka
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Department of Urology, Keio University School of Medicine, Tokyo, Japan
Minoru Kitago
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Ikumi Ono
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Nursing Department, Keio University Hospital, Tokyo, Japan
Kumiko Misu
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Nursing Department, Keio University Hospital, Tokyo, Japan
Arisa Ueki
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan
Tomoko Yoshihama
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Aiko Nagayama
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Yota Yasumizu
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Department of Urology, Keio University School of Medicine, Tokyo, Japan
Yumiko Goto
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan
Center for Preventive Medicine, Keio University School of Medicine, Tokyo, Japan
Kohei Nakamura
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Center for Cancer Genomics, Keio University School of Medicine, Tokyo, Japan
Mamiko Yamada
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan
Megumi Yokota
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Sayaka Uchida
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Mari Takeuchi
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Palliative Care Center, Keio University School of Medicine, Tokyo, Japan
Takeru Funakoshi
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
Wataru Yamagami
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
Center for Hereditary Breast and Ovarian Cancer Syndrome, Keio University Hospital, Tokyo, Japan

Keywords: hereditary breast and ovarian cancer, surveillance, risk-reducing surgery

JOURNAL FREE ACCESS FULL-TEXT HTML Advance online publication

Article ID: 2025-0004-OA

DOI https://doi.org/10.2302/kjm.2025-0004-OA

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Abstract

The management of hereditary breast and ovarian cancer (HBOC) in Japan has changed drastically with the expansion of indications for poly ADP-ribose polymerase inhibitors, the increase in diagnostic opportunities with the spread of companion diagnoses, and partial insurance coverage of HBOC management. These circumstances require a response that is coordinated across the entire hospital rather than from individual departments. In April 2021, we established the HBOC Center, which is operated by nine departments: Obstetrics and Gynecology, Reproduction, Surgery (breast group, hepato-pancreato-biliary group), Urology, Dermatology, Neuropsychiatry, the Center for Medical Genetics, and the Cancer Center. In addition to discussions of individual cases, our monthly conferences have enabled us to establish indication criteria and appropriate items for surveillance, visualize the examination flow in the hospital, construct a patient database, and provide open lectures to educate the public. The future HBOC management system should not only fulfill the existing requirements for risk-reducing surgery and facility standards but also offer comprehensive and diversified attention based on the needs of patients and their family members.

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