抄録
A research assistant in the Department of Pathology, School of Medicine, Keio University, Tokyo, made a necropsy of a toxoplasmosis child and had accidentally a splash of the cerebrospinal fluid on his face. Six months later he had disseminated lung infiltrations and two and half years later he suddenly lost the normal sight of his left eye due to chorioretinitis which was considered to be due to tuberculosis at that time. One year after the onset of the chorioretinitis the patient had for the first time Sabin-Feldman dye test which was positive with a titer of 1:256. Cerebrospinal fluid was examined by direct smear and mouse passages, but no Toxoplasmas were found.
Chorioretinits persisted changing continuously its localization and intensity. About four months after the first dye test, the second test was made which gave a titer of 1:1024 and on the next day subretinal fluid was withdrawn and inoculated into mice. By the serial passages, typical Toxoplasmas were demonstrated. The dye test titer became 1:4096 ten days after the drainage.
Although daraprim and sulfadiazine were used for treatment, they have had no effect and the chorioretinitis still persist at present or 20 months after the oneset. In all probability, the infection occurred at the necropsy, provoked the disseminated lung infiltrations and became chronic thereafter producing cysts in brain and retina. Cysts in retina might have undergo rupture and the chorioretinitis ensued first by the allergic response and later by the prolife-ration of the parasites.
Daraprim and sulfadiazine treatment had no recognizable effects.
